Lidocaine And Prilocaine

Lidocaine and prilocaine cream (a eutectic mixture of lidocaine 2.5% and prilocaine 2.5%) is indicated as a topical anesthetic for use on:

  • genital mucous membranes for superficial minor surgery and as pretreatment for infiltration anesthesia.

lidocaine and prilocaine cream is not recommended in any clinical situation when penetration or migration beyond the tympanic membrane into the middle ear is possible because of the ototoxic effects observed in animal studies (see WARNINGS).

Lidocaine And Prilocaine Description

Lidocaine 2.5% and Prilocaine 2.5% Cream, USP is an emulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine cream in a ratio of 1:1 by weight. This eutectic mixture has a melting point below room temperature and therefore both local anesthetics exist as a liquid oil rather than as crystals. It is packaged in 5 gram and 30 gram tubes.

Lidocaine is chemically designated as acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl), has an octanol: water partition ratio of 43 at pH 7.4, and has the following structure:

Prilocaine is chemically designated as propanamide, N-(2-methylphenyl)-2-(propylamino), has an octanol: water partition ratio of 25 at pH 7.4, and has the following structure:

Each gram of lidocaine and prilocaine cream contains lidocaine 25 mg, prilocaine 25 mg, polyoxyethylene fatty acid esters (as emulsifiers), carboxypolymethylene (as a thickening agent), sodium hydroxide to adjust to a pH approximating 9, and purified water to 1 gram. Lidocaine and prilocaine cream contains no preservative, however it passes the USP antimicrobial effectiveness test due to the pH. The specific gravity of lidocaine and prilocaine cream is 1.00.

Lidocaine And Prilocaine Reviews

View All Reviews

Active Lidocaine And Prilocaine Ingredients

  1. Lidocaine
  2. Prilocaine

Lidocaine And Prilocaine NDC Codes

NDC Quantity Package
17478-0190-05 1 1 Carton
17478-0190-55 5 1 Carton
17478-0190-30 1 1 Carton
54868-5194-00 5 Tube 1 Carton
54868-5194-01 1 Tube 1 Carton
54868-5194-02 1 Tube 1 Carton
50383-0667-30 1 1 Carton
50383-0667-15 1 1 Carton
00781-7058-39 1 Tube 1 Carton
00781-7058-05 5 Tube 1 Carton
00781-7058-03 1 Tube 1 Carton
21695-0388-30 1 Tube 1 Carton
00168-0357-05 5 g Tube
00168-0357-55 1 1 Carton
00168-0357-05 5 g Tube
00168-0357-56 1 1 Carton
00168-0357-30 1 1 Carton
00115-1468-53 1 Tube 1 Carton
00115-1468-60 5 Tube 1 Carton
00115-1468-45 1 Tube 1 Carton
68788-9774-03 1 1 Carton
42254-0195-30 1 1 Carton
33261-0591-01 1 Tube 1 Carton

Lidocaine And Prilocaine Structured Product Labels

SPL Manufacturer
7bb482ba-632b-4d8f-a7d4-3fc857bdeef7 Akorn, Inc.
2a9976e3-4595-4bc5-b7f9-f4a9bd59e55d Physicians Total Care, Inc.
9378d186-5b25-49bc-8563-a659fa1194c2 Hi-Tech Pharmacal Co., Inc.
e38c7741-6d25-46d7-aeee-c14f7ee7aac3 Sandoz Inc.
b61c6a09-7764-4a92-93a9-a1356aeeaa9c Rebel Distributors Corp
833cd52c-6470-49c4-937f-1393971f4db9 E. FOUGERA & CO. A division of Fougera Pharmaceuticals Inc.
b6c88c84-cd82-4390-aea5-b04f15f57143 Global Pharmaceuticals, Division of Impax Laboratories Inc.
3e1cfe73-1d7f-4807-a26d-0d4c2b4894d9 Preferred Pharmaceuticals, Inc.
8debb03e-a237-4e0d-be06-8ae17eaa14fa Rebel Distributors Corp
625c2437-2999-4b82-8331-51cd32aa3292 Aidarex Pharmaceuticals LLC

Lidocaine And Prilocaine Overview

Overall Rating
Medication Type
Approval Date
Aug 18, 2003
DEA Schedule
Not Classified

Get The Daily Newsletter