Savella Abuse and Dependence

9.2 Abuse

Milnacipran did not produce behavioral signs indicative of abuse potential in animal or human studies.

9.3 Dependence

Milnacipran produces physical dependence, as evidenced by the emergence of withdrawal symptoms following drug discontinuation, similar to other SNRIs and SSRIs. These withdrawal symptoms can be severe. Thus, Savella should be tapered and not abruptly discontinued after extended use [see Warnings and Precautions (5.7)].

Controlled Substance

Milnacipran is not a controlled substance.

Savella Overview

Overall Rating
Medication Type
Approval Date
Apr 17, 2009
DEA Schedule
Not Classified

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